I know this is an incredibly hard time and it's a tough decision- best of luck to you- don't give up hope. I have had my heart broken multiple times. Note that this paper is still preprint as of Nov 2021. Thinking of you , Thank you Yes, its A LOT and its weighing heavy on me since last week (when I got the call from my RE). Did you do anything different with your FET? Criticisms of PGS - FertilityIQ So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. I know I needed it after my failed FET and I really didnt have it. Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. I have a similar story. Only one normal PGS embryo - any advice on preparing for - Inspire PGT-A miscarriage rates (euploid, mosaic, and aneuploid transfers) MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. This educational content is not medical or diagnostic advice. IVF with PGS Success Rates: Who Benefits from PGS/PGD I am currently 6w5d pregnant, which is the farthest Ive been. He suggested an endometrial biopsy instead. PGS can increase the rate of clinical pregnancy. thats a great suggestion! Im currently 17 weeks from another FET. My RE felt that having one good embryo was not a guarantee, so 4 rounds of retrievals it took before we had a few to work with. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Thank you Its so hard when youre paying yet your doctor doesnt think its needed. I'm 37 years old, and I just had a chemical pregnancy with a PGS-tested embryo. Women above 35 seem to benefit the most with PGS . Then my 3rd transfer and 2nd FET is now my baby boy growing well at 16 weeks 4 days. I'm curious if this might have something to do with it. However, I just recently gave birth, so dont give up there are still lots of reasons to be hopeful esp if you make pgs normal blasts. It would be a miracle to have a similar experience as yours , I know you said age is a factor, but you could always take a month or two off for your mental health and then re-assess. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). Im assuming you had no issues shipping yours? We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). Last January we found out we were pregnant but had a miscarriage at 7 weeks. I actually didnt have embryos to bring with me when we switched. I only have embryo left ugh . my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. With a PGS tested embryo this time. However, almost all studies and clinic data show that IVF success rates indicates higher pregnancy rates. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. Please specify a reason for deleting this reply from the community. I dont see myself spending a fortune on acupuncture again. She is pregnant right now from that cycle. Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. Miscarriages and embryo implantation failures vs PGT-A - MyIVFanswers.com The Munne et al. I am just torn. More studies need to be done. Are you sure you want to block this member? Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. PGT-A can also identify the gender of an embryo. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. Genetic testing was normal. I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. Chemical Pregnancy: Causes, Symptoms & Treatment - Cleveland Clinic Best of luck! Neal et al. What Is a Chemical Pregnancy: Early Miscarriage - Healthline Check here for the full glossary (please excuse the repeated terms!). You cant compare the per retrieval and per transfer stats against each other directly. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Trade-offs of PGT-A (or PGS) I felt like a number in his practice, and I think he was milking my insurance for all he could get. Do you think it's worth it as last time I had a medicated cycle and it was a . Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Some are faster, and some are slower. It's my second transfer. Did your doctor have your SO go through the rounds of antibiotics as well? Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. You can check out my summary of the study here.. Of the 414 blastocysts transferred: 312 were euploid, 73.1% had a clinical pregnancy and 7.2% miscarried; 102 were aneuploid, 23.5% had a clinical pregnancy and . However, the two transfers we did werent PGS tested. Does it still matter? I had also changed from an estradiol tablet to estradiol patches in my first FET. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. My husbands sperm analysis was only very slightly abnormal. in reply to 3 years ago Thank you so much! I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. I can't tell if that is from the progesterone. Odds of success are roughly 70 percent. Terms are highlighted every 3rd time to avoid repetition. Im so sorry youre going through that. Thanks! Praying you did and thank you for the advice! How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility Its not a ton of time to do and it might make the difference. It looks like at this time that it's implantation failure rather than abnormal embryos, since we got a good one from the ones we had tested. It definitely won't hurt to ask your doctors about an antihistamine protocol, I don't remember the exact dosages I took or how long. My doctor thought it was possibly due to retained products of conception. We have one (and only one) 4bb PGS normal embryo. In this post well learn more about IVF with PGS success rates for euploid embryos. Note that this is per transfer data. Good luck and wishing baby dust your way soon! But I do have a friend who had 1 embryo shipped from Utah to California for an FET and it was a different clinic that handled the FET. I go for my next Beta tomorrow. My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. I have had MENTS one BFN and one chemical on untested embryos on my first round of IVF (I'm 34). No PGS testing Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. This is important because miscarriage rates with advancing female age. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. Does this harm the embryo or reduce its potential for success? I am new to the online support groups and considered joining months ago but struggled to even bring myself to put my story out there. Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. He was surprised my doctor was doing a Receptiva test naturally, without medication, since the idea is to simulate the same environment of a transfer, and was also surprised that my doctor had done a 5-day-post-retrieval-transfer in the first place. A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. A 2019 multicenter and international RCT (the STAR trial) compared euploid and untested embryo transfers. We decided to start with IUI with clomid which resulted in another chemical pregnancy. It was a chemical pregnancy. Dogpark in reply to Mogwai_2 3 years ago. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. I might actually look into that. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. You may want to ask/consider this before moving on for more data before trying with another precious embryo. Use of this site is subject to our terms of use and privacy policy. I actually didnt do acupuncture the second cycle, but I was in great shape. Chemical Pregnancy: What it is, Symptoms, and More - WebMD Terms are highlighted every 3rd time to avoid repetition. Please don't give up! Thanks! Reply Share React AMB425 Sep 2, 2016 11:01 AM For the successful ivf only ONE healthy embryo is enough. I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. I know how devastating loss can be but theres always, always hope. Hi all, HCG was 24 Friday and yesterday went down to 16. frustration and tears were worth it. definitely worth asking! Note that once you confirm, this action cannot be undone. Sending you lots of love, hope and positivity! Any advice is greatly appreciated. Dr is responsible for allowing . I suspected that my Hashimotos had something to do with the chemicals so we figured we will do IVF#4 and PGS test the embryos. Did our first FET in October with a supposedly PGT normal embryo. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I actually didn't do acupuncture the second cycle, but I was in great shape. Or they did but they were all aneuploid? Yes, and I believe it was due to doctor negligence. Your experience is so inspiring, thank you for sharing . Thats what i needed to hear. While a PGS normal embryo means the chromosomes are normal, there is more to a baby than just chromosomes and sometimes it just doesnt work. Best of luck to you. This is exactly what I had! I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. PGS (PGT-A) success rates - PGS Testing (PGT-A) - Remembryo Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. I am remaining hopeful, when we sent our embryos for testing, they only thought that one would come back normal. There is much better chance of IVF success with PGS testing in women who were over the age of 35. Chemical pregnancy is an early miscarriage. Talk about adjusting meds? PGT-A and PGS Genetic Screening of Embryos - FertilityIQ If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Its so heartbreaking but Im trying to find some hope so I can move forward. I am not naive I know bad things can happen. Poor quality embryos are they worth PGS testing? I think the ERA is a great idea too. And Im so sorry about your first FET. For now its probably best to avoid having to thaw and biopsy if possible. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. I have expressed my concern but my RE believes it is more about the pattern. I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. MENTS my 3rd FET was a success end MENTS. Ive had two chemicals and my RE suggested doing an endometrial receptivity assay (ERA). I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. Hi everyone. I want to be exhaustive in testing to get to the bottom of the issue, but I certainly don't want to waste time/money on tests we don't need. I am 39 turning 40 this year. How did your pregnancy turn out? The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. hang in there. Hopefully an ERA can shed some light on it! Preimplantation Genetic Testing - RSC Bay Area I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. One thing Ive definitely learned from all of this is to trust my gut instinct. PGS testing done this round 8 high quality normal embryos. Go figure, right?! After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. Hello, Hello, I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. However, that information will still be included in details such as numbers of replies. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. Please specify a reason for deleting this reply from the community. PGS or Transfer 2 embryos? - Infertility - Inspire If your protocol did not have one or the other perhaps you can ask your RE about it. A chemical pregnancy is a very early miscarriage that happens within the first five weeks of pregnancy. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. But I dont think we can compare those two sets of numbers to really tell if PGS is increasing our success rates per age group. Congratulations on your success , I have a similar story. Zhao et al. This ended up working for me after my biochemical pregnancy. Wishing you the best of luck and baby dust. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. They stratified the mosaics based on the specific type of abnormality, and whether they were <50% mosaic or >50% mosaic (meaning the mosaic embryos had a mix of either less or more than 50% aneuploid cells with euploid cells). Thanks for sharing! Like embryo grades in the previous section, it looks like IVF with PGS success rates may vary based on how fast the embryo develops, particularly for Day 7. We strive to provide you with a high quality community experience. Simon et al. Oops, meant to say Im 17 weeks pregnant from my last FET! Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? Don't lose hope! sd84. Women who have three chromosomally-normal embryos as a result of In Vitro Fertilization (IVF) have a 94.9% chance of achieving pregnancy, research conducted by Reproductive Medicine Associates (RMA) and presented at the annual meeting of the American Society for Reproductive Medicine (ASRM) shows. They may be able to use the same sample as the ERA if you do both. Miscarriage of PGT tested embryo : r/IVF - Reddit My first fresh transfer ended in miscarriage due to low progesterone, I was on supplements but not enough. After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. She was also concerned with the previous doctors aggressive surgery protocols, and my age was also a factor. My first FET was a day 6 5AA euploid embryo. I did switch clinics in the middle and felt that my new clinic cared more about me and was more aggressive in testing for other things and adding new medications to my cycles. I just wish we had more answers so we can prepare for the next . We spent well over 45K to get to this point. Group Black's collective includes Essence, The Shade Room and Naturally Curly. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. I was doing yoga and walking everyday and meditating. And demand that my lining be over 8 before I allow another transfer to occur? I an 33 and my husband is 37. I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. Or is it worth having the actual tests done? I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. Do embryo biopsies for PGT-A match the rest of the embryo? These studies were particularly small so drawing conclusions isnt really possible yet. Thankful for these forums! You can check out my summary of the study here. I hope this gives you some hope. MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). 5AB euploid embryo. Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). Segmental aneuploids: the main source for PGT-A false positives? My 2nd also failed and I had them do a thrombophilia panel on me and found I had a MTHFR mutation so we added folgard and he adjusted my days on progesterone and in addition to the suppositories I did the shots as well. Multiple chemical pregnancies from embryos that had been PGS tested They havent discontinued my medication they want me to continue until further instructions. I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this!
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